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and B.F. P.R. Correspondence to Weekly COVID-19-associated hospitalization rates among U.S. infants and children aged 0-4 years have declined since the peak of January 8, 2022; however, peak rates during Omicron predominance were approximately five times those of the peak during Delta predominance. The state has administered 3.2 million vaccine doses since Dec. 1 alone, but lagging rates between full vaccination and first doses for adults especially (82.6% vs. 95%) are becoming a point of . This correction ensures that there is always a reasonable denominator for the unvaccinated population that would prevent hospitalization rates from growing unrealistically large because of potential overestimates of vaccination coverage. Data among adults over 50 showed that a booster shot gave even stronger protection. Mothers were classified as either having had 2 doses or one dose of mRNA COVID-19 vaccines during pregnancy (and completed more than 14 days prior to delivery) or not having had any COVID-19 vaccines prior to delivery. Compared with the Delta-predominant period, the proportion of unvaccinated hospitalized Black adults increased during the Omicron-predominant period. The KPNC Institutional review board approved and waived consent for this study. Although all data used in this analysis were anonymised, the individual-level nature of the data used risks individuals being identified, or being able to self-identify, if the data are released publicly. [email protected]. Background: Risk stratification models have been developed to identify patients that are at a higher risk of COVID-19 infection and severe illness. The vaccines have proved highly safe and effective at reducing the risk of severe illness, hospitalization and death. MB), Help with If material is not included in the articles Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Initial hospital data from England and Denmark also suggest Omicron cases are less severe. The efficacy of COVID 19 vaccines for reducing the risk of severe COVID-19 infection is demonstrated in real life. After the emergence of the Omicron variant, the rate of COVID-19 hospitalizations in the United States was 10.5 times higher in unvaccinated adults and 2.5 times higher in those who were vaccinated but received no booster than in booster recipients, according to a new study. MMWR Morb Mortal Wkly Rep 2020;69:134754. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. The report found that, during the omicron wave 6,743.5 per 100,000 unvaccinated people were contracting COVID-19 and 187.8 per 100,000 were hospitalized. Article The research was published yesterday in JAMA Internal Medicine. In this analysis, we estimated the odds ratio (OR) of vaccination of mothers of infants who tested positive for SARS-CoV-2 versus infants who tested negative using logistic regression models conditioned (stratified) on the calendar date of the test so that infants testing positive on a certain day were compared to infants testing negative on that same day. Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of 4% of cases) without NHS numbers were excluded from our primary analysis. These proportions are lower compared with 47.3% of White persons who received a primary series and 54.5% of eligible adults who received a booster dose. Relative to the Delta-predominant period, Black adults accounted for a larger proportion of unvaccinated adults during the Omicron-predominant period, and age-adjusted hospitalization rates for Black adults increased to the highest rate among all racial and ethnic groups for any week during the pandemic. We did not assess whether vaccines received before pregnancy or immediately after pregnancy were associated with a reduced risk of testing positive for SARS-CoV-2 in infants. Vaccination status is not available for Iowa and cases from Iowa are excluded from analyses that examined vaccination status. J. Med. Weekly / March 25, 2022 / 71(12);466473. Vaccine 31, 31043109 (2013). 387, 187189 (2022). Additional COVID-NET methods for determining vaccination status have been described previously. Waning 2-dose and 3-dose effectiveness of mRNA vaccines against COVID-19-associated emergency department and urgent care encounters and hospitalizations among adults during periods of delta and omicron variant predominanceVISION Network, 10 states, August 2021-January 2022. During the Delta dominant period, the crude incidences of testing positive for SARS-CoV-2 during the first 2, 4, and 6 months of life were lower among infants whose mothers received at least two doses of mRNA COVID-19 vaccines during pregnancy (0.75, 1.43, and 1.56 infants per 100 person-years [PY], respectively) than those whose mothers were not vaccinated during pregnancy (5.47, 5.10, and 4.78 infants per 100 PYs, respectively). Objectives To develop and implement a scoring tool to identify COVID-19 patients that are at risk for severe illness during the Omicron wave. SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland, Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy, Effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy: a national observational study in Israel, Covid-19 vaccination programme effectiveness against SARS-CoV-2 related infections, hospital admissions and deaths in the Apulia region of Italy: a one-year retrospective cohort study, Post-vaccination outcomes in association with four COVID-19 vaccines in the Kingdom of Bahrain, Effectiveness and protection duration of Covid-19 vaccines and previous infection against any SARS-CoV-2 infection in young adults, The indirect effect of mRNA-based COVID-19 vaccination on healthcare workers unvaccinated household members, SARS-CoV-2 infection and COVID-19 vaccination in pregnancy, Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar, https://downloads.aap.org/AAP/PDF/AAP%20and%20CHA%20-%20Children%20and%20COVID-19%20State%20Data%20Report%209.29.22%20FINAL.pdf?_ga=2.255000394.335550773.1665001859-370326403.1636740765, https://doi.org/10.1016/j.jpeds.2022.09.059, http://creativecommons.org/licenses/by/4.0/. Rep. 70, 895899 (2021). There was no link between risk of COVID-19 death and race, except for Indian patients, who were at slightly higher risk than their White peers. Baxter, R., Bartlett. ICU admission status was missing in 1.3% (weighted) of hospitalizations; these hospitalizations are included in other analyses. J. Obstet. Thank you for visiting nature.com. https://www.medrxiv.org/content/10.1101/2022.01.11.22269045v1, https://data.cdc.gov/Vaccinations/COVID-19-Vaccination-Demographics-in-the-United-St/km4m-vcsb. TN and NMF validated the data. Hospitalization rates during peak Omicron circulation (January 2022) among unvaccinated adults remained 12 times the rates among vaccinated adults who received booster or additional doses and four times the rates among adults who received a primary series, but no booster or additional dose. 1.04-1.49) after adjusting for age, sex, and vaccine characteristics. Centers for Disease Control and Prevention. Most mothers (1032 of 1138) who received only one dose received the vaccine during the third trimester. Razzaghi, H. et al. All rights Reserved. Overall, 63% of Americans are fully vaccinated. Shimabukuro, T. T. et al. Table 2. Science brief: omicron (B.1.1.529) variant. CIDRAP - Center for Infectious Disease Research & Policy Two to 4 weeks after a booster dose, vaccine effectiveness ranged from around 65-75%, dropped to 55-70% at 5 to 9 weeks, and 40-50% from 10 weeks or more after a booster dose. Over the entire study period, the crude rate of hospitalization with a SARS-CoV-2 positive test was lower during the first 6 months of life among infants whose mothers received at least two doses . Clinical trends among U.S. adults hospitalized with COVID-19, March to December 2020: a cross-sectional study. Effectiveness of COVID-19 vaccines in preventing hospitalization among adults aged 65 yearsCOVID-NET, 13 states, FebruaryApril 2021. While this proportion might not be representative of the proportion of vaccinated pregnant women within KPNC because of our exclusion criteria, more efforts are needed to promote COVID-19 vaccines for pregnant persons because vaccination provides protection to mothers and their infants until they are old enough to receive their own COVID-19 vaccines. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. COVID-19 vaccines have demonstrated both high efficacy in clinical trials and high real-world effectiveness, especially against the original and Delta variant of the virus6,7,8,9,10. Durability of anti-spike antibodies in infants after maternal COVID-19 vaccination or natural infection. Data about boosters was only available for those over 50. Among 829 adults hospitalized during the Omicron-predominant period, 49.4% were unvaccinated, compared with 69.5% during the Delta-predominant period (p<0.01). Among fully vaccinated people without a booster, rates were lower at 3,355.5 per 100,000 for COVID-19 cases and 35.4 per 100,000 for hospitalizations. Still, even with a smaller percentage of people getting severely ill during the Omicron wave, a large number of cases over a short time can lead to a spike in people being hospitalized or admitted . The infection fatality rate from Covid-19 fell more than 10-fold from a little more than 1 per cent in January 2021 to 0.1 per cent in July as the UK's vaccination campaign was rolled out, and . This can lead to overestimates of first doses and underestimates of subsequent doses, and underestimates of hospitalization rates in persons who received additional or booster doses. These cookies may also be used for advertising purposes by these third parties. 1). During the first 6 months of life, 940 (3.10%) infants tested positive for SARS-CoV-2 by polymerase chain reaction (PCR) test and 10 (0.03%) infants were hospitalized with a positive SARS-CoV-2 test. If the SARS-CoV-2 test date was not available, hospital admission date was used. Nat Commun 14, 894 (2023). We calculated vaccine effectiveness (VE) as 100% multiplied by 1HR. New charts from the Centers for Disease Control and Prevention (CDC), more severe disease and more hospitalizations, Insider's Catherine Schuster Bruce reported. A and B, Markers indicate estimates, with vertical lines indicating 95% CIs. Nursing home residents have been disproportionately affected by COVID-19; older age, comorbidities, and the congregate nature of nursing homes place residents at higher risk for infection and severe COVID-19-associated outcomes . Surveillance officers abstracted data on sampled patients from medical charts. The finding that maternal vaccination was less effective at protecting infants during the Omicron dominant period is also consistent with previous studies which have reported decreased effectiveness of mRNA COVID-19 vaccines during Omicron among children and adults14,20. The study was conducted among a cohort of infants born between December 15, 2020, and May 31, 2022. Rep. 71, 429436 (2022). By the end of December, Omicron made up 58% of all cases in the US, per Our World in Data, but Delta is thought to cause more severe disease and more hospitalizations than Omicron on average. In the Omicron variant period, the effectiveness of maternal vaccination in these three age intervals was 21% (CI: 21,48), 14% (CI: 9,32) and 13% (CI: 3,26), respectively. Sect. Morb. https://doi.org/10.1016/j.jpeds.2022.09.059 (2022). Selected counties in California, Colorado, Connecticut, Georgia, Iowa, Maryland, Michigan, Minnesota, New Mexico, New York, Ohio, Oregon, Tennessee, and Utah (https://www.cdc.gov/mmwr/volumes/69/wr/mm6915e3.htm). Our study was strengthened both by its large sample size and our ability to follow infants through 6 months of age. Am. Among the infants in the cohort, 19,418 (64.06%) of the mothers were unvaccinated during pregnancy, 1138 (3.75%) of the mothers received one dose of an mRNA COVID-19 vaccine and 9755 (32.18%) received 2 doses during pregnancy (Table1). Cite this article. part 46, 21 C.F.R. Variances were estimated using Taylor series linearization method. As of January 26, 2022, 39.6% of Black persons received a primary vaccine series; of those, 43.9% of adults received a booster dose once eligible. Danino, D. et al. Effectiveness of Two Doses of BNT162b2 Vaccine before and during Proxy Omicron Period. During the period of Omicron predominance, hospitalization rates increased most sharply among Black adults in the United States relative to all other racial and ethnic groups examined and reached the highest rate observed among all racial and ethnic groups since the beginning of the pandemic. Coinciding with Omicron variant predominance, COVID-19associated hospitalization rates among adults increased in late December 2021 and peaked in January 2022; rates increased more among Black adults relative to rates among adults of other racial and ethnic groups. Characteristics and maternal and birth outcomes of hospitalized pregnant women with laboratory-confirmed COVID-19COVID-NET, 13 states, March 1August 22, 2020. In this primary design, all eligible infants meeting inclusion criteria were included without sampling which improved power and minimized bias related to selection. Annually, approximately 40,000 births occur at KPNC facilities. DeSilva, M. et al. First, COVID-19associated hospitalizations might have been missed because of hospital testing practices and test availability. Risk of hospitalisation associated with infection with SARS-CoV-2 lineage B.1.1.7 in Denmark: an observational cohort study. According to the CDC, hospitalization rates among the unvaccinated were 16 times higher in December overall. PubMed Two new observational studies suggest that COVID-19 vaccination lowers long-COVID incidence and severity. ** Total hospitalizations include data from selected counties in 14 COVID-NET states irrespective of vaccination status and includes adults with partial or unknown vaccination status. Foppa, I. M., Haber, M., Ferdinands, J. M. & Shay, D. K. The case test-negative design for studies of the effectiveness of influenza vaccine. As with previous variants, being vaccinated greatly protects you from severe disease with omicron. During the Omicron-predominant period, overall weekly adult hospitalization rates peaked at 38.4 per 100,000, exceeding the previous peak on January 9, 2021 (26.1) and the peak rate during the Delta-predominant period (15.5) (Figure 1). Because the immune status of all patients is not known, an additional dose (recommended for persons with a weakened immune system) cannot be distinguished from a booster dose. The cumulative monthly age-adjusted hospitalization rate during January 2022 among unvaccinated adults (528.2) was 12 times the rates among those who had received a booster or additional dose (45.0) and four times the rates among adults who received a primary series, but no booster or additional dose (133.5). Maternal vaccination was protective, but protection was lower during the Omicron period than during Delta. Health and Human Services. https://doi.org . Methods: One hundred and . The images or other third party material in this article are included in the articles Creative Commons license, unless indicated otherwise in a credit line to the material. Partially vaccinated adults, and those who received a single dose of a 1-dose product <14 days before the positive SARS-CoV-2 test result were not included in analyses by vaccination status but were included in rates and overall proportions that were not stratified by vaccination status. The researchers used the QCovid risk model to estimate hazard ratios (HRs) for clinical risk factors. Morb. J. Med. During Omicron predominance, children aged <6 months accounted for 44% of hospitalizations among children ages 04 years3. The increase in transmissibility of the Omicron variant might have amplified these risks for hospitalization, resulting in increased hospitalization rates among Black adults compared with White adults, irrespective of vaccination status. Percentages presented were weighted to account for the probability of selection for sampled cases (3). Additional limitations include the inability to estimate the effectiveness of vaccines received prior to pregnancy onset. 1CDC COVID-19 Emergency Response Team; 2General Dynamics Information Technology, Atlanta, Georgia; 3California Emerging Infections Program, Oakland, California; 4Career Epidemiology Field Officer Program, CDC; 5Colorado Department of Public Health & Environment; 6Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut; 7Emory University School of Medicine, Atlanta, Georgia; 8Georgia Emerging Infections Program, Georgia Department of Public Health; 9Atlanta Veterans Affairs Medical Center, Atlanta, Georgia; 10Iowa Department of Public Health; 11Michigan Department of Health and Human Services; 12Minnesota Department of Health; 13New Mexico Emerging Infections Program, University of New Mexico, Albuquerque, New Mexico; 14New York State Department of Health; 15University of Rochester School of Medicine and Dentistry, Rochester, New York; 16Ohio Department of Health; 17Public Health Division, Oregon Health Authority; 18Vanderbilt University Medical Center, Nashville, Tennessee; 19Utah Department of Health. Spontaneous abortion following COVID-19 vaccination during pregnancy. COVID-19 incidence and death rates among unvaccinated and fully vaccinated adults with and without booster doses during periods of Delta and Omicron variant emergence25 U.S. Jurisdictions, April 4December 25, 2021. Klein, N. P. et al. From Jan 1 to Mar 16, 2022, when Omicron was predominant, 4,781 (0.02%) of 19,473,570 booster recipients died of COVID-19, and 58,020 (0.3%) died of other causes. Female sex was a protective factor (HR, 0.52), while residence in a nursing home or low-income area was a risk factor. Vaccinated patients were older (68 vs. 57 years), and 62% had at least one comorbidity Admission to the ICU was 20%, and the mortality rate at 30 days was 14%. Wkly. Ferdinands, J. M. et al. During the Omicron-predominant period, weekly COVID-19associated hospitalization rates (hospitalizations per 100,000 adults) peaked at 38.4, compared with 15.5 during Delta predominance. Andrews, N. et al. Risk was especially high for people with severe combined immunodeficiency (HR, 6.2). Using previously described methods (3), investigators collected clinical data on a representative sample of adult patients (7.9%) hospitalized during July 1, 2021January 31, 2022, stratified by age and COVID-NET site. Vaccinations were limited only to those received during pregnancy. During the study period, home testing became more prevalent. During the Omicron dominant period, maternal vaccination with at least two doses reduced the infants risk of testing SARS-CoV-2 positive by 43% (95% CI: 4, 69) during the first 2 months of life, 36% (95% CI:11, 55) during the first 4 months of life, and 41% (95% CI: 25, 53) during the first 6 months of life (Supplemental Table2). COVID-19Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron Variant Predominance, by Race/Ethnicity and Vaccination Status COVID-NET, 14 States, July 2021January 2022. This was the highest age-adjusted weekly rate observed among any racial and ethnic group during the pandemic. CAS Open 5, e2233273 (2022). According to the Ontario Science Table's online dashboard, the hospital occupancy rate for the unvaccinated was 611 per million unvaccinated people in the province's population as of Jan. 7,. Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19COVID-NET, 14 States, March 1-July 25, 2020. ** Monthly incidence among adults who received booster or additional doses was calculated by summing the total number of COVID-19 patients with booster or additional doses hospitalized over all days of the month and dividing by the sum of adults with booster or additional doses in the underlying population for each day of the month. This method was also used for calculations in unvaccinated persons and those who received a primary series but not a booster or additional dose.. On March 18, 2022, this report was posted online as an MMWR Early Release. Receipt of one dose especially during the third trimester was also associated with a reduced risk of infants testing positive for SARS-CoV-2 during the first 6 months of life during the Delta dominant period. This analysis describes weekly hospitalization rates during Delta- and Omicron-predominant periods. However, vaccination during pregnancy was less effective at protecting infants against SARS-CoV-2 infection during the Omicron period. Three recent epidemiological studies found that vaccination during pregnancy was associated with a reduced risk of SARS-CoV-2 infection in infants during their first 4 months of life and a reduced risk of hospitalization during the first 5 months of life17,18,19. Structural changes in the brain may explain the persistent fatigue and neuropsychiatric complications tied to long COVID. Graff, K. et al. Overall, the study results support recommendations for vaccination during pregnancy to protect both mothers and their infants. The results were published yesterday in JAMA Network Open. In January 2022, unvaccinated adults and those vaccinated with a primary series, but no booster or additional dose, were 12 and three times as likely to be hospitalized, respectively, as were adults who received booster or additional doses. J. Med. Our findings that receipt of at least two doses of COVID-19 vaccine during pregnancy was effective at protecting infants during the Delta period are similar to those reported in a recent Norwegian study showing that mRNA COVID-19 vaccination during pregnancy was associated with a 71% decreased risk of testing positive for SARS-CoV-2 in infants during their first 4 months of life during the Delta period17. Vaccination offers the best way to protect against COVID-19 and its complications. These data should be taken with a grain of salt. You can review and change the way we collect information below. These findings are consistent with estimates of booster effectiveness against symptomatic Omicron infection using healthcare ascertainment. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. supervised chart reviews. A free-text field for other types of residences was examined; patients with an LTCF-type residence were also categorized as LTCF residents. Arthur Reingold, Jeremy Roland, Ashley Coates, California Emerging Infections Program, Oakland, California; Breanna Kawasaki, Rachel Herlihy, Isaac Armistead, Madelyn Lensing, Jordan Surgnier, Sarah McLafferty, Colorado Department of Public Health & Environment; Ann Basting, Tessa Carter, Maria Correa, Daewi Kim, Carol Lyons, Hazhia Sorosindi, Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut; Emily Fawcett, Katelyn Ward, Jana Manning, Asmith Joseph, Allison Roebling, Chandler Surell, Stephanie Lehman, Taylor Eisenstein, Suzanne Segler, Grayson Kallas, Marina Bruck, Rayna Ceaser, Annabel Patterson, Sabrina Hendrick, Johanna Hernandez, Hope Wilson, School of Medicine, Emory University, Georgia Emerging Infections Program, Georgia Department of Public Health, Veterans Affairs Medical Center, Foundation for Atlanta Veterans Education and Research, Atlanta, Georgia; Jim Collins, Shannon Johnson, Justin Henderson, Sue Kim, Alexander Kohrman, Lauren Leegwater, Val Tellez Nunez, Sierra Peguies-Khan, Michigan Department of Health and Human Services; Kayla Bilski, Kristen Ehresmann, Richard Danila, Jake Garfin, Grace Hernandez, Kieu My Phi, Ruth Lynfield, Sara Vetter, Xiong Wang, Minnesota Department of Health; Daniel M. Sosin, Susan L. Ropp, Sunshine Martinez, Jasmyn Sanchez, Cory Cline, Melissa Judson, Florent Nkouaga, Mark Montoya, New Mexico Department of Health; Sarah Lathrop, Kathy M. Angeles, Yadira Salazar-Sanchez, Sarah A. Khanlian, Nancy Eisenberg, Dominic Rudin, Sarah Shrum Davis, Mayvilynne Poblete, Emily B. Hancock, Francesca Pacheco, New Mexico Emerging Infections Program; Yassir Talha, Celina Chavez, Jennifer Akpo, Alesia Reed, Murtada Khalifa, CDC Foundation, New Mexico Department of Health; Suzanne McGuire, Kerianne Engesser, Nancy Spina, Adam Rowe, New York State Department of Health; Sophrena Bushey, Virginia Cafferky, Maria Gaitan, Christine Long, Thomas Peer, Kevin Popham, University of Rochester School of Medicine and Dentistry, Rochester, New York; Julie Freshwater, Denise Ingabire-Smith, Ann Salvator, Rebekah Sutter, Ohio Department of Health; Sam Hawkins, Public Health Division, Oregon Health Authority; Tiffanie Markus, Katie Dyer, Karen Leib, Terri McMinn, Danielle Ndi, Gail Hughett, Emmanuel Sackey, Kathy Billings, Anise Elie, Manideepthi Pemmaraju, Vanderbilt University Medical Center, Nashville, Tennessee; Amanda Carter, Andrea George, Andrew Haraghey, Ashley Swain, Caitlin Shaw, Laine McCullough, Mary Hill, Ryan Chatelain, Salt Lake County Health Department, Salt Lake City, Utah; Alvin Shultz, Robert W. Pinner, Rainy Henry, Sonja Mali Nti-Berko, CDC; Elizabeth Daly, Council of State and Territorial Epidemiologists. MMWR Morb Mortal Wkly Rep 2022;71:1328. Laurie M. Billing and Kenzie Teno report grants from the Council of State and Territorial Epidemiologists during the conduct of the study. Real-world data suggest lower COVID-19 vaccine effectiveness against Omicron variants11,12,13,14. Among these infants, for our main analysis, we excluded 21,891 (35.2%) based on maternal exclusion criteria and 10,412 (16.8%) after applying infant exclusion criteria (Fig. No other potential conflicts of interest were disclosed. The group raised concerns about a small number of Guillain-Barre syndrome cases in vaccine recipients and wanted more data, especially on efficacy in those at highest risk. For infants, we included age, as a categorical time-changing variable in 30-day increments. The study did not adjust for maternal SARS-CoV-2 infections during pregnancy due to the inability of capturing home testing results. To obtain https://www.medrxiv.org/content/10.1101/2021.08.27.21262356v1 E. & Klein, N. P. Effectiveness of vaccination during pregnancy to prevent infant pertussis. It's not clear which variant might have been associated with these hospitalizations. J. Med. Article Adults who received booster doses were classified as those who completed their primary vaccination series and received an additional or booster dose of vaccine on or after August 13, 2021, at any time after the completion of their primary series, and 14 days before a positive test result for SARS-CoV-2, because COVID-19associated hospitalizations are a lagging indicator, and time passed after receipt of a booster dose has been shown to be associated with reduced rates of COVID-19 infection (https://www.nejm.org/doi/full/10.1056/NEJMoa2114255). Vaccination status is based on state immunization information system data. Starting the week ending December 4, 2021, Maryland data are not included in weekly rate calculations but are included in previous weeks. Saving Lives, Protecting People, https://covid.cdc.gov/covid-data-tracker/#variant-proportions, https://www.cdc.gov/coronavirus/2019-ncov/covid-data/covid-net/purpose-methods.html, https://www.cdc.gov/mmwr/volumes/69/wr/mm6915e3.htm, https://www.cdc.gov/nchs/nvss/bridged_race.htm, https://www.medrxiv.org/content/10.1101/2021.08.27.21262356v1, https://www.cdc.gov/mmwr/volumes/70/wr/mm7050e2.htm, https://www.nejm.org/doi/full/10.1056/NEJMoa2114255, https://medrxiv.org/cgi/content/short/2021.08.27.21262356v1, https://www.medrxiv.org/content/10.1101/2022.01.11.22269045v1, https://data.cdc.gov/Vaccinations/COVID-19-Vaccination-Demographics-in-the-United-St/km4m-vcsb, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/stay-up-to-date.html, https://doi.org/10.1001/jamanetworkopen.2021.30479, Centers for Disease Control and Prevention, U.S. Department of Health & Human Services, American Indian or Alaska Native, non-Hispanic, Psychiatric admission requiring medical care. Google Scholar. American Academy of Pediatrics. We conducted a descriptive analysis of the study population and calculated crude rates of SARS-CoV-2 infection and hospitalization by maternal vaccination status. *** An additional 172 (3.4%, 95% CI = 2.7%4.2%) adults were partially vaccinated, 69 (0.9%, 95% CI=0.61.2) received a primary vaccination series <14 days before receiving a positive SARS-CoV-2 test result, and 186 (4.1%) had unknown vaccination status; these groups are not further described in this analysis. Effectiveness of COVID-19 Pfizer-BioNTech BNT162b2 mRNA vaccination in preventing COVID-19-associated emergency department and urgent care encounters and hospitalizations among nonimmunocompromised children and adolescents aged 5-17 yearsVISION Network, 10 states, April 2021-January 2022.